张博

张博 Bo Zhang
副教授、博士生导师   
Associate Professor / PhD Supervisor
皇家化学会会员  MRSC
通讯地址：beat365官方网站化学系 邮编361005 
Address: Department of Chemistry, Xiamen University, Xiamen 361005, China
电话/传真：0086-592-2188691  
Phone/Fax: 0086-592-2188691
E-mail: bozhang@xmu.edu.cn

个人简历：
beat365官方网站化学系 副教授 （2009年11月至今）
Associate Professor, Xiamen University (2009.11-now)
英国帝国理工学院化学系 博士后 （2007年-2009年）
PostDoc, Imperial College London, UK (2007-2009)
英国约克大学化学系 博士 （2002年-2007年）
PhD, The University of York, UK (2002-2007)
中国科学院大连化学物理研究所国家色谱中心 研究助理 （1999年-2002年）
Research Assistant, National Chromatographic Center, Dalian Institute of Chemical Physics, Chinese Academy of Science (1999-2002) 
吉林大学化学系 学士 （1995年-1999年）
BSc, Jilin University, China (1995-1999)

研究兴趣：
色谱与分离科学；微流控芯片与先进制造；蛋白质组学与生物医学分析；液相分离-质谱联用技术 Chromatography and Separation Science; Microfluidics and Advanced Fabrication; Proteomics and Biomedical Analysis; Liquid Phase Separation Hyphenation with Mass Spectrometry

近期主要代表论著：

1. 1.  Polarity-extended liquid chromatography-triple quadrupole mass spectrometry for simultaneous  hydrophilic and hydrophobic metabolite analysis. Rui Guo, Qisheng Zhong, Jiaqi Liu, Peiming Bai, Zongpeng Wang, Jieling Kou, Peijie Chen, Jie  Zhang, Bo Zhang*. Analytica Chimica Acta, 2023, 1277, 341655.

2. 2. Recent advancements in nanoelectrospray ionization interface and coupled devices. Shiyi Chen, Juxing Zeng, Zhendian Zhang, Bolin Xu, Bo Zhang*. Journal of  Chromatography Open, 2022, 2, 100064.

3. 3. Mass  Fabrication of Capillary Columns Based on Centrifugal Packing. Ya Liu,  Hanrong Wen, Shiyi Chen, Xiaojuan Wang, Xudong Zhu, Lianzhong Luo, Xiaofei  Wang, Bo Zhang*. Analytical Chemistry, 2022, 94, 8126-8131.

4. 4. Segmented Microfluidics-Based Packing Technology for Chromatographic Columns. Xiaofei Wang, Jue Zhu, Chenyuhu Yang, Fei Qin, Bo Zhang*. Analytical  Chemistry, 2021, 93, 8450-8458.

5. 5. Direct Infusion ICP‑qMS of Lined-up Single-Cell Using an Oil-Free Passive Microfluidic System. Yang Zhou, Zhangqian Chen, Juxing Zeng, Jiaxuan Zhang, Danxia Yu, Bo Zhang*, Xiaowen Yan, Limin Yang, Qiuquan Wang*. Analytical  Chemistry, 2020, 92, 5286-5293.

6. 6. Performance  of nanoflow liquid chromatography using core-shell particles: A comparison  study. Ya Liu, Kaiyue Sun, Chuyi Shao,  Xiaohui Shi, Juxing Zeng, Rui Guo, Bo Zhang*. Journal of Chromatography A,  2021, 1648, 462218.

7. 7. Separation  and screening of antioxidant peptides from scomberomorus niphonius based  on nanoflow liquid chromatography. Yaru Xue, Rui Guo, Bo Zhang*.  Chinese Journal of Chromatography, 2020, 38, 1431-1439.

8. 8. Towards  a high peak capacity of 130 using nanoflow hydrophilic interaction liquid  chromatography. Ya Liu, Xiaofei Wang, Zhangqian Chen, Derek Hecheng Liang,  Kaiyue Sun, Shanqing Huang, Jue Zhu, Xiaohui Shi, Juxing Zeng, Qiuquan  Wang, Bo Zhang*. Analytica Chimica Acta,  2019, 1062, 147-155.

9. 9. Microscale  Sample Transfer Technology for Capillary Two Dimensional Liquid  Chromatography. Ya  Liu, Bo Zhang*. Chinese Journal of Analytical  Chemistry, 2019, 47, 1803-1808.

10. 10. Metabolomics  Study of Rat Urine with Long Term Arsenic Exposure. Xiaofei Wang, Yunwang Shen, Jue Zhu, Bo Zhang*. Chinese Journal of Analytical  Chemistry, 2019, 47, 1045-1053.

11. 11. Research  and Application Progress of Micellar Electrokinetic Chromatography in  Separation of Proteins. Fan Gao, Xiaofei Wang, Bo Zhang*. Chinese Journal  of Analytical Chemistry, 2019, 47, 805-813.

12. 12. Microfluidic  Array Liquid Chromatography: A Proof of Principle Study. Zhuoheng Zhou, Ya  Liu, Bo Zhang*. Chinese Journal of Analytical Chemistry, 2019, 47,  500-507.

13. 13. Performance  of Long Packed Nanoflow Liquid Chromatographic Columns in Proteomics   Analysis. Xiaofei Wang,      Fei Qin, Rui Guo, Bo Zhang*. Chinese Journal of  Analytical Chemistry, 2019, 47, 388-393.

14. 14. Recent  advances in hyphenation nanoflow liquid phase separation with inductively  coupled plasma mass spectrometry. Fangfang Ding, Jue Zhu, Rui Guo, Bo Zhang*.  Chinese Journal of Chromatography, 2019, 37, 132-142.

15. 15. Multicolumn  technologies in chromatographic analysis. Xiaofei Wang, Kaiyue Sun, Bo   Zhang*. Chinese Journal of Chromatography, 2019, 37, 123-131.

16. 16. Electrochromatographic behavior of core-shell particles: A comparison study. Lijun Yang, Lingjia  Xu, Rui Guo, Tianyu Gao, Haoxing Guo, Yue Yu, Jijian Lv, Qiuquan Wang, Bo  Zhang*.  Analytica Chimica Acta,  2018, 1033, 205-212.

17. 17. Two dimensional  separations of human urinary protein digest using a droplet-interfaced  platform. Linquan Ye, Xin Wang, Jing Han, Fan Gao, Lingjia Xu, Zhiliang  Xiao, Peiming Bai, Qiuquan Wang, Bo Zhang*. Analytica Chimica Acta, 2015,  863, 86-94.

18. 18. Towards high peak  capacity separations in normal pressure nanoflow liquid chromatography  using meter long packed capillary columns. Jing Han, Linquan Ye, Lingjia  Xu, Zhuoheng Zhou, Fan Gao, Zhiliang Xiao, Qiuquan Wang, Bo Zhang*.  Analytica Chimica Acta, 2014, 852, 267-273.

19. 19. A comparison study of in-column and on-column detection for electrochromatography. Qier Zhang,  Lingjia Xu, Zhuoheng Zhou, Lijun Yang, Qiuquan Wang, Bo Zhang*. Journal of  Chromatography A, 2014, 1362, 225-230.

20. 20. Fabrication and  investigation of electrochromatographic columns with a simplex  configuration. Qing Liu, Lijun Yang, Qiuquan Wang, Bo Zhang*. Journal of  Chromatography A, 2014, 1349, 90-95.

21. 21. Toward rapid preparation  of capillary columns for electrochromatography use. Qing Liu, Lin Wang,  Zhuoheng Zhou, Qiuquan Wang, Lijuan Yan, Bo Zhang*. Electrophoresis 2014,  35, 836-839.

22. 22. A “plug-and-use” approach  towards facile fabrication of capillary columns for high performance nanoflow liquid chromatography. Zhiliang Xiao, Lin Wang, Ya Liu, Qiuquan  Wang, Bo Zhang*. Journal of Chromatography A, 2014, 1325, 109-114.

23. 23. Capillary electrophoresis-based immobilized enzyme reactor using particle-packing technique. Lina Liu, Bo Zhang, Qian Zhang, Yanhong Shi, Liping Guo, Li  Yang*. Journal of Chromatography A, 2014, 1352, 80-86.

24. 24. A chemical “hub”  for absolute quantification of a targeted protein: orthogonal integration of elemental and molecular mass spectrometry. Xiaowen Yan, Zhaoxin Li, Yong Liang, Limin Yang, Bo Zhang, Qiuquan Wang*. Chemical Communications,  2014, 50, 6578-6581.

25. 25. EphA2 enhances the  proliferation and invasion ability of LNCaP prostate cancer cells. Peijie  Chen, Yan Huang, Bo Zhang, Qiuquan Wang, Peiming Bai*. Oncology Letters,  2014, 8, 41-46.

26. 26. Click chemistry mediated  Eu-tagging: activity-based specific quantification and simultaneous  activity evaluation of CYP3A4 using Eu-153 species-unspecific isotope  dilution inductively coupled plasma mass spectrometry. Yong Liang, Xiaowen  Yan, Zhaoxin Li, Limin Yang, Bo Zhang, Qiuquan Wang*. Analytical Chemistry,  2014, 86, 3688-3692.

27. 27. Performance of single  particle fritted capillary columns in electrochromatography. Bo Zhang*,  Qing Liu, Lijun Yang, Qiuquan Wang. Journal of Chromatography A, 2013,  1272, 136-140.

28. 28. Droplet microfluidics  based microseparation systems. Zhiliang Xiao, Menglei Niu, Bo Zhang*.  Journal of Separation Science, 2012, 35, 1284-1293.

29. 29. Sensitive ionization of  non-volatile analytes using protein solutions as spray liquid in  desorption electrospray ionization mass spectrometry. Zhiqiang Zhu, Jing  Han, Yan Zhang, Yafei Zhou, Ning Xu, Bo Zhang, Haiwei Gu, Huanwen Chen*.  Rapid Communications in Mass Spectrometry, 2012, 26, 2770-2776.

30. 30. Integrin-targeted  trifunctional probe for cancer cells: a "seeing and counting"  approach. Zhubao Zhang, Qiang Luo, Xiaowen Yan, Zhaoxin Li, Yacui Luo,  Limin Yang, Bo Zhang, Haifeng Chen, Qiuquan Wang*. Analytical Chemistry, 2012, 84, 8946-8951.

31. 31. Europium-labeled activity-based probe through click chemistry: absolute serine protease  quantification using 153Eu isotope dilution ICP/MS. Xiaowen Yan, Yacui Luo, Zhubao Zhang, Zhaoxin Li, Qiang Luo, Limin Yang, Bo Zhang, Haifeng Chen, Peiming Bai, Qiuquan Wang*. Angew. Chem. Int. Ed. 2012, 51, 3358-3363.

32. 32. Droplet microfluidics: technologies and applications. Zhiliang Xiao, Bo Zhang*. Chinese Journal  of Chromatography, 2011, 29, 949-956.

33. 33. Development of a  droplet-interfaced high performance liquid chromatography-capillary  electrophoresis two dimensional separation platform. Linquan Ye, Qingshi  Wu, Simin Dai, Zhiliang Xiao, Bo Zhang*. Chinese Journal of  Chromatography, 2011, 29, 857-861.

34. 34. Photocatalytical  reduction of disulphide bonds in peptides on Ag-loaded nano-TiO₂   for subsequent derivatization and determination. Lijuan Wang, Xiaowen Yan,  Chunlai Xu, Zhiliang Xiao, Limin Yang, Bo Zhang, Qiuquan Wang*. Analyst, 2011, 136, 3602-3604.

35. 35. Electrically assisted  capillary liquid chromatography using a silica monolithic column. Bo  Zhang, Edmund T. Bergstrom, David M. Goodall*. Journal of Chromatography  A, 2010, 1217, 2243-2247.

36. 36. Droplet-based  compartmentalization of chemically separated components in two-dimensional  separations. X. Z. Niu, B. Zhang (co-first author), R. T. Marszalek, O. Ces, J. B. Edel, D. R. Klug and A. J. deMello*. Chem. Commun., 2009,  6159–6161.

37. 37. Capillary action liquid  chromatography. Bo Zhang, Edmund T. Bergstrom, David M. Goodall*, Peter  Myers. Journal of Separation Science, 2009, 32, 1831-1837.

38. 38. Single-particle fritting technology for capillary electrochromatography. Bo Zhang, Edmund T. Bergstrom, David M. Goodall*, Peter Myers. Analytical Chemistry, 2007, 79,  9229-9233.

39. 39. Determination of alcohols  by high performance liquid chromatography with fluorimetric detection  after pre-column derivatisation with carbazole-9-N-acetic acid and  chromatographic behaviour of alcoholic derivatives. Jinmao You, Bo Zhang,  Weibing Zhang, Pei Yang, Yukui Zhang*. Journal of Chromatography A, 2001,   909, 171-182.

40. 40. On line enrichment of  neutral solute in capillary electrochromatography. Weibing Zhang, Jun Zhu,  Jinmao You, Bo Zhang, Guichen Ping, Yukui Zhang*. Chinese Journal of  Analytical Chemistry, 2001, 29, 869-875.

41. 41. Study on on-column  concentration of ionic sample in capillary electrochromatography - model  development and investigation. Weibing Zhang, Bo Zhang, Jun Zhu, Yukui   Zhang*. Acta Chimica Sinica, 2001, 59, 257-261.

42. 42. A new method for the  measurement of dead time in reversed phase high performance liquid  chromatography. Bo Zhang, Qinghe Zhang, Yichu Shan, Weibing Zhang, Yukui  Zhang*. Modern Scientific Instruments, 2000, 2, 26-27.