学术讲座
报告题目：Basic Group in Stereoselective Gold Chemistry: From Ligand-Enabled Cooperative Catalysis to A General Approach to SN2 Glycosylation
报告时间：2022-05-13 10:00
报 告 人：Professor Liming Zhang（张立明）
University of California Santa Barbara
报告地点：思明校区化学报告厅（线上报告）
翔安校区、漳州校区同步转播
报告摘要：Metal-ligand cooperation is a versatile strategy for achieving efficient and/or stereoselective catalysis. Since 2014, we have developed a range of enabling remotely basic group-functionalized biaryl-2-ylphospine ligands (see Scheme A) for cooperative gold catalysis. With chiral elements built into these ligands, asymmetric transformations are developed in mechanistically rational manners. DFT calculations confirm the critical participation of the ligand remote basic group in catalysis. Several recent developments will be discussed. This type of bifunctional ligands also enables cooperative catalysis by other metals including Cu and Ag.
A different yet related approach to achieving stereoselective gold catalysis is developed specifically to address the long-standing challenge in carbohydrate synthesis, i.e., the lack of stereoselective synthesis of glycosidic bonds applicable to every sugar type. In this approach, as shown in Scheme B, a basic group is installed onto the anomeric leaving group of the carbohydrate donor and serves to direct the backend attack by a carbohydrate acceptor upon the leaving group activation by gold. The SN2 nature of the glycosylation and the general tolerance of many sugar types make this approach appealing. The progress made in this area will be discussed.
报告人简介：
Liming Zhang教授目前就职于美国加州大学圣巴巴拉分校化学与生物化学系。他于1993年在南昌大学化学系获得学士学位，1996年获南开大学有机化学硕士学位，1998年美国阿拉巴马大学获第二个硕士学位，2003年于密歇根大学获得博士学位。2003-2005年在芝加哥大学进行博士后研究，2005-2009年在内华达大学雷诺分校化学系担任助教，2009-2011年在美国加州大学圣巴巴拉分校化学与生物化学系担任副教授，2013年被评为教授。Liming Zhang教授课题组的主要研究领域为均相金催化反应，已在各类权威化学期刊上发表论文一百二十余篇。鉴于Liming Zhang教授在化学领域的杰出贡献，他被授予了多项重要奖项，例如，2008年美国科学基金委NSF CAREER Award、2008年Amgen Young Investigator’s Award、2009年中美化学与化学生物学教授协会杰出青年教授奖等。
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