卢嘉锡讲座
报告题目：3D printing of drug eluting devices: from prototyping to personalized medicine
报告时间：2024-12-11 14:30
报告人： Prof. Jean-Christophe Leroux
瑞士苏黎世联邦理工学院
报告地点：卢嘉锡楼202报告厅
转播地点：翔安校区能源材料大楼3号楼会议室5，漳州校区生化主楼307教室
报告摘要：
Three-dimensional (3D) printing is a potent method for creating affordable, personalized medical devices on demand. Among various 3D printing techniques, digital light processing (DLP) is notable for its fast fabrication of high-resolution objects. However, the production of bioresorbable medical devices using DLP is currently limited by the absence of appropriate biomedical inks. Here, we developed novel polyester-based inks that allow for DLP printing of therapeutic devices with tunable mechanical properties and degradation profiles. The most promising materials were used to design biodegradable customized airway stents. These stents degraded to soft innocuous hydrogels in vitro and disappeared 7 weeks after insertion in rabbits. The 3D printed stents could be loaded with drugs such as levofloxacin or nintedanib whose release kinetics could be adjusted by varying the copolymer composition. In addition, shape memory temperature-responsive stents were also 3D printed. By tuning the glass transition temperature of the polymeric matrix, it was possible to engineer folded stents that could be easily deployed at body temperature. Lastly, DLP was used as prototyping method to fabricate and optimize various oral formulations. Buccal suction patches mimicking the suction cup of octopuses were investigated for the administration of peptidic drugs while pH-sensitive colonic capsules capable of encapsulating aqueous suspensions were investigated for the delivery of live probiotics. These studies open new perspectives for the rapid manufacturing of complex devices with superior properties.
报告人简介：
Jean-Christophe Leroux is full professor of Drug Formulation and Delivery at the ETH Zurich, Switzerland. He was trained as pharmacist at the University of Montreal (Canada), obtained his Ph.D. in Pharmaceutical Sciences from the University of Geneva (Switzerland) and worked as postdoctoral fellow at UCSF (USA). Dr. Leroux was professor of Pharmaceutical Technology at the University of Montreal from 1997 to 2008. He has made important fundamental and applied contributions to the fields of biomaterials and drug delivery, and has also been involved in the development of innovative bio-detoxification systems. He is a fellow of the AAPS, EURASC, French Academy of Pharmacy and CRS, and the co-founder of Obaris AG, Versantis AG and Inositec AG, three ETH spin-off pharmaceutical companies.
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