题目：Tumor targeted drug delivery and imaging using polydiacetylene micelles
报告人：法国原子能与可替代能源委员会Dr. Eric DORIS
时间：2014年11月5日上午9:30-10:30
地点：同安二201
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2014年10月29日
摘要：Over the past few years, medicine has been a field where nanotechnologies have shown great promise particularly for diagnosis and drug delivery applications. The challenge of nanomedicine consists in carrying active molecules through the different biological barriers and reaching specific targets in an efficient and non-toxic way. In addition, some active agents require specific formulations to overcome intrinsic problems associated with aqueous insolubility, in vivo stability and bioavailability. With the advent of nanotechnologies, a whole range of new carriers with different properties and functionalities are now available. However, the development of small biocompatible carriers with high loading capacity, extended circulation time, and favorablebiodistribution has several unanswered issues. This talk will give an overview of our recent findings regarding photopolymerized micelles obtained from the self-assembly of diacetylene-containing amphiphiles. Their synthesis and characterization will be presented as well as some biomedical applications such as tumor imaging and drug delivery.
Biography:
Dr. Eric Doris studied organic chemistry at the University of Strasbourg (France). He obtained his PhD degree in 1995 from the same University, under the guidance of Dr. Charles Mioskowski. In 1996 he completed his post-doctoral training with Sir Derek H. R. Barton at Texas A&M University (USA). Since 1997, he has been working at the Alternative Energies and Atomic Energy Commission of France (CEA) where he is leading the Nanoscience research group. His current research interests include the synthesis of biologically active compounds, supramolecular assemblies on carbon nanotubes, and nanomedicine for drug delivery and imaging applications.
