高锦豪

高锦豪/Jinhao Gao
教授、博士生导师
电话：86-592-2180278
传真：86-592-2189959
办公室：卢嘉锡楼528室
电子邮箱：jhgao@xmu.edu.cn
课题组网站： https://jhgao.xmu.edu.cn/

个人简历：

学士（南京大学 2004）
博士（香港科技大学 2008）
博士后（斯坦福大学 2010）
教授（beat365官方网站 2010.6-）

获奖情况：

香港青年科学家奖 (2007) ，教育部“新世纪优秀人才支持计划”（2010），福建省“闽江学者”特聘教授（2011），福建省杰出青年科学基金（2012），国家优秀青年科学基金（2012），中国化学会青年化学奖（2014），福建省青年拔尖创新人才（2014），霍英东教育基金会青年教师奖（2016），国家杰出青年科学基金（2021）

研究兴趣：
影像化学生物学；磁共振造影剂；¹⁹F磁共振探针；金属化学生物学；肿瘤诊疗；分子探针

近期主要代表论著： 

1. 1. Chen, D.; Guo, J.; Li, A.; Sun, C.; Lin, H.; Lin, H.*; Yang, C.*; Wang, W.*; Gao, J. H.* Metabolic Fluorine Labeling and Hotspot Imaging of Dynamic Gut Microbiota in Mice. Science Advances 2023, 9, eabg6808.

2. 2. Luo, X.; Gong, X.; Su, L.; Lin, H.; Yang, Z.; Yan, X.; Gao, J. H.* Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 1403-1410.

3. 3. Lin, H. Y.; Tang, X.; Li, A.; Gao, J. H.* Activatable ¹⁹F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects. Adv. Mater. 2021, 33, 2005657.

4. 4. Zhu, X. L.; Tang, X.; Lin, H. Y.; Shi, S.; Xiong, H.; Zhou, Q.; Li, A.; Wang, Q.; Chen, X.; Gao, J. H.* A Fluorinated Ionic Liquid-Based Activatable ¹⁹F MRI Platform Detects Biological Targets. Chem 2020, 6, 1134-1148.

5. 5. Sun, C. J.; Lin, H. Y.; Gong, X. Q.; Yang, Z.; Mo, Y.; Chen, X.; Gao, J. H.* DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators. J. Am. Chem. Soc. 2020, 142, 198-206.

6. 6. Tang, X.; Li, A.; Zuo, C.; Liu, X.; Luo, X.; Chen, L.; Li, L.; Lin, H.*; Gao, J. H.* Water-Soluble Chemically Precise Fluorinated Molecular Clusters for Interference-Free Multiplex ¹⁹F MRI in Living Mice. ACS Nano 2023, 17, 5014-5024.

7. 7. Jiang, Y.; Luo, X.; Chen, L.; Lin, H.*; Gao, J. H.* Multicolor ¹⁹F magnetic resonance imaging: A promising medical technique for in vivo visualization of multiple biological targets. Fundamental Research 2023, 3, 529-533.

8. 8. Liu, K.; Cai, Z.; Chi, X.; Kang, B.; Fu, S.; Luo, X.; Lin, Z.-W.; Ai, H.*; Gao, J. H.*; Lin, H.* Photoinduced Superhydrophilicity of Gd-Doped TiO2 Ellipsoidal Nanoparticles Boosts T₁ Contrast Enhancement for Magnetic Resonance Imaging. Nano Lett. 2022, 22, 3219-3227.

9. 9. Sun, C. J.; Yang, Z. X.; Wu, P.; Luo, X. J.; Liu, K.; Wang, B. J.; Lin, H. Y.*; Gao, J. H.* Multinuclear Mn(II) United-DOTA Complexes with Enhanced Inertness and High MRI Contrast Ability. Cell Rep. Phys. Sci. 2022, 3, 100920.

10. 10. Yang, Z. X.; Luo, X. J.; Lin, Y. Y.; Huang, J. Q.; Lin, H. Y.*; Gao, J. H.* Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular Prodrug. ACS Chem. Biol. 2022, 17, 762-767.

11. 11. Liu, K.; Kang, B.; Luo, X.; Yang, Z.; Sun, C.; Li, A.; Fan, Y.; Chen, X.; Gao, J. H.*; Lin, H.* Redox-Activated Contrast-Enhanced T₁-Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver. ACS Nano 2021, 15, 17831-17841.

12. 12. Tang, X.; Gong, X. Q.; Li, A.; Lin, H. Y.; Peng, C.; Zhang, X.; Chen, X.; Gao, J. H.* Cascaded Multiresponsive Self-Assembled ¹⁹F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification. Nano Lett. 2020, 20, 363-371.

13. 13. Zhou, Z.; Yang, L.; Gao, J. H.*; Chen, X.* Structure–Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging. Adv. Mater. 2019, 31, 1804567.

14. 14. Zhang, Y. J.*; Zhang, L.; Gao, J. H.*; Wen, L. P.* Pro-Death or Pro-Survival: Contrasting Paradigms on Nanomaterial-Induced Autophagy and Exploitations for Cancer Therapy. Acc. Chem. Res. 2019, 52, 3164-3176.

15. 15. Wei, R.; Gong, X.; Lin, H.; Zhang, K.; Li, A.; Liu, K.; Shan, H.; Chen, X.; Gao, J. H.* Versatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery. Nano Lett. 2019, 19, 5394-5402.

16. 16. Zhou, Z.; Wu, C.; Liu, H.; Zhu, X.; Zhao, Z.; Wang, L.; Xu, Y.; Ai, H.; Gao, J. H.* Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Nano 2015, 9, 3012-3022.

17. 17. Zhao, Z.; Wang, X.; Zhang, Z.; Zhang, H.; Liu, H.; Zhu, X.; Li, H.; Chi, X.; Yin, Z.; Gao, J. H.* Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T₁ Imaging. ACS Nano 2015, 9, 2749-2759.

18. 18. Zhou, Z.; Zhao, Z.; Zhang, H.; Wang, Z.; Chen, X.; Wang, R.; Chen, Z.; Gao, J. H.* Interplay between Longitudinal and Transverse Contrasts in Fe₃O₄ Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.

19. 19. Zhao, Z. H.; Zhou, Z. J.; Bao, J. F.; Wang, Z. Y.; Hu, J.; Chi, X. Q.; Ni, K. Y.; Wang, R. F.; Chen, X. Y.; Chen, Z.; Gao, J. H.* Octapod Iron Oxide Nanoparticles as High-Performance T₂ Contrast Agents for Magnetic Resonance Imaging. Nat. Commun. 2013, 4, 2266.

20. 20. Zhou, Z. J.; Huang, D. T.; Bao, J. F.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.* A Synergistically Enhanced T₁-T₂ Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.